Publications
All
2025
STAG2 regulates polycomb and differentiation in urothelial precursors and bladder cancer
PLOS One
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15 Oct 2025
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doi:10.1371/journal.pone.0333128
A comprehensive benchmark of single-cell Hi-C embedding tools
Nature Communications
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14 Oct 2025
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doi:10.1038/s41467-025-64186-4
Genome-wide meta-analyses of cross substance use disorders in diverse populations
Molecular Psychiatry
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07 Oct 2025
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doi:10.1038/s41380-025-03294-5
Regulation of epigenetics and chromosome structure by human ORC2
Cell Reports
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01 Oct 2025
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doi:10.1016/j.celrep.2025.116504
Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease
Alzheimer's & Dementia
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01 Sep 2025
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doi:10.1002/alz.70593
H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells
Science Advances
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04 Jul 2025
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doi:10.1126/sciadv.adt8765
The Somatic Mosaicism across Human Tissues Network
Nature
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02 Jul 2025
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doi:10.1038/s41586-025-09096-7
Biomedical data and AI
Science China Life Sciences
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14 Mar 2025
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doi:10.1007/s11427-024-2859-1
2024
Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.
Alzheimer's & dementia : the journal of the Alzheimer's Association
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03 Jul 2024
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pubmed:38958117
STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme.
The Journal of biological chemistry
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03 May 2024
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pubmed:38705393
magpie: A power evaluation method for differential RNA methylation analysis in N6-methyladenosine sequencing.
PLoS computational biology
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12 Feb 2024
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pubmed:38346081
2023
Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A.
Nature communications
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05 Sep 2023
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pubmed:37669939
Novel correlative analysis identifies multiple genomic variations impacting ASD with macrocephaly.
Human molecular genetics
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05 May 2023
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pubmed:36519762
Ancestry-related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk.
Alzheimer's & dementia : the journal of the Alzheimer's Association
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10 Apr 2023
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pubmed:37037656
Easy Hi-C: A Low-Input Method for Capturing Genome Organization.
Methods in molecular biology (Clifton, N.J.)
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01 Jan 2023
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pubmed:36427146
2022
DeepLoop robustly maps chromatin interactions from sparse allele-resolved or single-cell Hi-C data at kilobase resolution.
Nature genetics
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11 Jul 2022
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pubmed:35817982
A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry.
PLoS genetics
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05 Jul 2022
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pubmed:35788729
53BP1 regulates heterochromatin through liquid phase separation.
Nature communications
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18 Jan 2022
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pubmed:35042897
Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets.
Alzheimer's & dementia : the journal of the Alzheimer's Association
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03 Jan 2022
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pubmed:34978147
2021
INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants.
Genome biology
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23 Aug 2021
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pubmed:34425882
2020
Single-cell lineage analysis reveals extensive multimodal transcriptional control during directed beta-cell differentiation.
Nature metabolism
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30 Nov 2020
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pubmed:33257854
Aberrant methylation underlies insulin gene expression in human insulinoma.
Nature communications
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15 Oct 2020
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pubmed:33060578
TWO-SIGMA: A novel two-component single cell model-based association method for single-cell RNA-seq data.
Genetic epidemiology
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29 Sep 2020
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pubmed:32989764
Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases.
Molecular cell
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26 Jun 2020
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pubmed:32592681
2019
Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes.
Cell reports
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12 Mar 2019
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pubmed:30865899
2018
Integrative functional genomic analysis of human brain development and neuropsychiatric risks.
Science (New York, N.Y.)
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14 Dec 2018
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pubmed:30545854
Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.
Stem cell reports
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23 Aug 2018
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pubmed:30146490
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Nature genetics
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26 Apr 2018
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pubmed:29700475
2016
HiView: an integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants.
BMC research notes
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11 Mar 2016
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pubmed:26969411
2015
A hidden Markov random field-based Bayesian method for the detection of long-range chromosomal interactions in Hi-C data.
Bioinformatics (Oxford, England)
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04 Nov 2015
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pubmed:26543175
2014
CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells.
PloS one
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08 Dec 2014
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pubmed:25486255
5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation.
Molecular cell
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25 Sep 2014
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pubmed:25263596
Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.
Nature chemical biology
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30 Mar 2014
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pubmed:24681537
2013
A high-resolution map of the three-dimensional chromatin interactome in human cells.
Nature
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20 Oct 2013
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pubmed:24141950
2012
Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.
Blood
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26 Jun 2012
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pubmed:22740448
CBX3 regulates efficient RNA processing genome-wide.
Genome research
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08 Jun 2012
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pubmed:22684280
2011
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.
Cell
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16 Sep 2011
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pubmed:21925322
PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers.
Proceedings of the National Academy of Sciences of the United States of America
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14 Mar 2011
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pubmed:21402921
Enhancers: multi-dimensional signal integrators.
Transcription
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01 Jan 2011
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pubmed:22231119
2007
A yeast two-hybrid smart-pool-array system for protein-interaction mapping.
Nature methods
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22 Apr 2007
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pubmed:17450148
2006
A pooling-deconvolution strategy for biological network elucidation.
Nature methods
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01 Mar 2006
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pubmed:16489335
2005
Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method.
Proceedings of the National Academy of Sciences of the United States of America
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09 May 2005
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pubmed:15883373
2004
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.
Proceedings of the National Academy of Sciences of the United States of America
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11 Nov 2004
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pubmed:15539461