May 2023
Publications
Apr 2026
Proinsulin regulators identified with CRISPR screen and in vivo mouse QTL mapping
Oct 2025
STAG2 regulates polycomb and differentiation in urothelial precursors and bladder cancer
Oct 2025
A comprehensive benchmark of single-cell Hi-C embedding tools
Oct 2025
Genome-wide meta-analyses of cross substance use disorders in diverse populations
Oct 2025
Regulation of epigenetics and chromosome structure by human ORC2
Sep 2025
Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease
Jul 2025
H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells
Jul 2025
The Somatic Mosaicism across Human Tissues Network
Mar 2025
Biomedical data and AI
Jul 2024
Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.
May 2024
STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme.
Feb 2024
magpie: A power evaluation method for differential RNA methylation analysis in N6-methyladenosine sequencing.
Sep 2023
Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A.
Apr 2023
Ancestry-related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease risk.
Nov 2022
Easy Hi-C: A Low-Input Method for Capturing Genome Organization
Jul 2022
DeepLoop robustly maps chromatin interactions from sparse allele-resolved or single-cell Hi-C data at kilobase resolution.
Jul 2022
A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry.
Jan 2022
53BP1 regulates heterochromatin through liquid phase separation.
Jan 2022
Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets.
Aug 2021
INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants.
Nov 2020
Single-cell lineage analysis reveals extensive multimodal transcriptional control during directed beta-cell differentiation.
Oct 2020
Aberrant methylation underlies insulin gene expression in human insulinoma.
Sep 2020
TWO-SIGMA: A novel two-component single cell model-based association method for single-cell RNA-seq data.
Jun 2020
Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases.
Mar 2019
Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes.
Dec 2018
Integrative functional genomic analysis of human brain development and neuropsychiatric risks.
Aug 2018
Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.
Apr 2018
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Mar 2016
HiView: an integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants.
Nov 2015
A hidden Markov random field-based Bayesian method for the detection of long-range chromosomal interactions in Hi-C data.
Dec 2014
CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells.
Sep 2014
5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation.
Mar 2014
Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.
Oct 2013
A high-resolution map of the three-dimensional chromatin interactome in human cells.
Jun 2012
Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.
Jun 2012
CBX3 regulates efficient RNA processing genome-wide.
Sep 2011
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.
Sep 2011
Enhancers
Mar 2011
PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers.
Apr 2007
A yeast two-hybrid smart-pool-array system for protein-interaction mapping.
Mar 2006
A pooling-deconvolution strategy for biological network elucidation.
May 2005
Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method.
Nov 2004