Publications

2026

Jul 16

Cross-platform Hi-C meta-analysis identifies functional insulators that actively block enhancer-promoter interactions

Jian Cui, Wanying Xu, Xiuyuan Lang, Shanshan Zhang, Leina Lu, Xiaoxiao Liu, Yan Li, Fulai Jin

Nature Communications · DOI: 10.1038/s41467-026-75801-3 · PMID: 42463675

Jun 23

Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells

Tianyi Yang, Jung-Sik Kim, Clara Mellows, Wanying Xu, Alvin Ya, ..., Jann Sarkaria, Fulai Jin, Todd Waldman

The Journal of Biological Chemistry · DOI: 10.1016/j.jbc.2026.113288 · PMID: 42336286

Apr 13

Proinsulin regulators identified with CRISPR screen and in vivo mouse QTL mapping

Sisi Lai, Mark P. Keller, Jinglin Zhang, Zhou Fang, Ying Xie, Chen Weng, Saixian Zhang, Shanshan Zhang, Peidong Gao, Luxin Ke, Yuntong Wang, ..., Fulai Jin, Alan D. Attie, Yan Li

Nature Communications · DOI: 10.1038/s41467-026-71726-z · PMID: 41974708

2025

Oct 15

STAG2 regulates polycomb and differentiation in urothelial precursors and bladder cancer

Youngrok Park, Wanying Xu, Tianyi Yang, Victoria Hill, Xiaoyuan He, ..., Jung-Sik Kim, Fulai Jin, Todd Waldman

PLOS One · DOI: 10.1371/journal.pone.0333128 · PMID: 41091719

Oct 14

A comprehensive benchmark of single-cell Hi-C embedding tools

Dylan Plummer, Xiuyuan Lang, Shanshan Zhang, Yan Li, Jing Li, Fulai Jin

Nature Communications · DOI: 10.1038/s41467-025-64186-4 · PMID: 41087414

Oct 7

Genome-wide meta-analyses of cross substance use disorders in diverse populations

Dongbing Lai, Michael Zhang, Nick Green, Marco Abreu, Tae-Hwi Schwantes-An, Clarissa C. Parker, Shanshan Zhang, Fulai Jin, ..., Howard J. Edenberg, Yunlong Liu, Tatiana Foroud

Molecular Psychiatry · DOI: 10.1038/s41380-025-03294-5 · PMID: 41057643

Oct 1

Regulation of epigenetics and chromosome structure by human ORC2

Zhangli Su, Mengxue Tian, Etsuko Shibata, Yoshiyuki Shibata, Tianyi Yang, Zhenjia Wang, Fulai Jin, Chongzhi Zang, Anindya Dutta

Cell Reports · DOI: 10.1016/j.celrep.2025.116504 · PMID: 41105516

Sep 1

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease

Aura M. Ramirez, Luciana Bertholim Nasciben, Sofia Moura, Lauren Coombs, Farid Rajabli, ..., Wanying Xu, Fulai Jin, ..., Juan I. Young, Derek M. Dykxhoorn, Jeffery M. Vance

Alzheimer's & Dementia · DOI: 10.1002/alz.70593 · PMID: 40937943

Jul 4

H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells

Emmalee W. Cooke, Cheng Zeng, Suza Mohammad Nur, Yunbo Jia, Aileen Huang, Jiwei Chen, Peidong Gao, Fei Xavier Chen, Fulai Jin, Kaixiang Cao

Science Advances · DOI: 10.1126/sciadv.adt8765 · PMID: 40614207

Jul 2

The Somatic Mosaicism across Human Tissues Network

Tim H. H. Coorens, Ji Won Oh, Yujin Angelina Choi, Nam Seop Lim, Boxun Zhao, ..., Fulai Jin, ..., Yan Li, ..., Eunjung Alice Lee, Flora M. Vaccarino, The Somatic Mosaicism across Human Tissues Network

Nature · DOI: 10.1038/s41586-025-09096-7 · PMID: 40604182

Mar 14

Biomedical data and AI

Hao Xu, Shibo Zhou, Zefeng Zhu, Vincenzo Vitelli, Liangyi Chen, ..., Fulai Jin, ..., Pulin Li, Qi Liu, Jing-Dong Jackie Han

Science China Life Sciences · DOI: 10.1007/s11427-024-2859-1 · PMID: 40100542

2024

Jul 3

Extended genome‐wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry

Nicholas R Ray, Brian W Kunkle, Kara Hamilton-Nelson, Jiji T Kurup, Farid Rajabli, ..., Wanying Xu, Fulai Jin, ..., Richard Mayeux, Margaret A Pericak-Vance, Christiane Reitz

Alzheimer's & Dementia: The Journal of the Alzheimer's Association · DOI: 10.1002/alz.13880 · PMID: 38958117

May 3

STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme

Wanying Xu, Jung-Sik Kim, Tianyi Yang, Alvin Ya, Lisa Sadzewicz, ..., Jann Sarkaria, Fulai Jin, Todd Waldman

The Journal of Biological Chemistry · DOI: 10.1016/j.jbc.2024.107341 · PMID: 38705393

Feb 12

magpie: A power evaluation method for differential RNA methylation analysis in N6-methyladenosine sequencing

Zhenxing Guo, Daoyu Duan, Wen Tang, Julia Zhu, William S Bush, Liangliang Zhang, Xiaofeng Zhu, Fulai Jin, Hao Feng

PLOS Computational Biology · DOI: 10.1371/journal.pcbi.1011875 · PMID: 38346081

2023

Sep 5

Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A

Chen Weng, Anniya Gu, Shanshan Zhang, Leina Lu, Luxin Ke, Peidong Gao, Xiaoxiao Liu, Yuntong Wang, Peinan Hu, Dylan Plummer, Elise MacDonald, Saixian Zhang, Jiajia Xi, Sisi Lai, Konstantin Leskov, Kyle Yuan, Fulai Jin, Yan Li

Nature Communications · DOI: 10.1038/s41467-023-41228-3 · PMID: 37669939

May 5

Novel correlative analysis identifies multiple genomic variations impacting ASD with macrocephaly

Chen Fu, Justine Ngo, Shanshan Zhang, Leina Lu, Alexander Miron, ..., Fulai Jin, Fredrick R Schumacher, Anthony Wynshaw-Boris

Human Molecular Genetics · DOI: 10.1093/hmg/ddac300 · PMID: 36519762